Evaluation of Medication Use in Patients with Gastroesophageal Reflux Disease (GERD) in the Inpatient Unit at a Hospital in Cimahi
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Jan 31, 2025
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Cimahi, Drug utilization, GERD, Hospital
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Abstract
Gastroesophageal Reflux Disease (GERD) is a pathological condition characterized by the regurgitation of gastric contents into the esophagus, resulting in symptoms affecting both the esophagus and extra-esophageal regions. The aim of this study is to ascertain the usage pattern and rationality of GERD medication consumption. This study utilizes an observational approach with a descriptive cross-sectional design. The data collection was performed retrospectively by examining the treatment histories of GERD patients documented in the medical records at the Inpatient Installation of Dustira Hospital from January to June 2023. The sample comprised 200 persons who met the inclusion criteria. Research indicated that individuals with GERD were predominantly female, comprising 73.5%, while males constituted approximately 26.5%. The predominant age range was 18-45 years, comprising 63.5%, followed by 46-59 years at 23.5%. 61 patients received a combination of omeprazole and sucralfate as the predominant medication. The analysis showed that 100% of patients utilized the medication with the appropriate indication, 97.5% with accurate drug selection, 100% with precise dosage, 100% with the right method of administration, and 100% with the appropriate administration interval
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Syarifuddin, S., Septiani, V. ., Khoirunnisa, S. ., Skarayadi, O. ., Kristian, R. ., & Vikasari, S. N. (2025). Evaluation of Medication Use in Patients with Gastroesophageal Reflux Disease (GERD) in the Inpatient Unit at a Hospital in Cimahi. Journal of Midwifery and Nursing, 7(1), 71-78. https://doi.org/10.35335/jmn.v7i1.5888
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BNF. (2017). British National Formulary (74th ed.). BMJ Group and The Royal Pharmaceutical Society.
Cvetkovic-Vega, A., Maguiña, J. L., , Soto, S., Lama-Valdivia, J., López, L. E. C.. (2021). Cross-Sectional Studies. Cross-sectional studies. Revista de la Facultad de Medicina Humana, 21(I), 179-185. https://doi.org/10.25176/RFMH.v21i1.3069
Destiani, D. P., Naja, S., Nurhadiyah, A., Halimah, E., & Febrina, E. (2016). Pola Peresepan Rawat Jalan?: Studi Observasional Menggunakan Kriteria Prescribing Indicator WHO di Salah Satu Fasilitas Kesehatan Bandung Prescribing of Outpatient?: Observational Study Using WHO Prescribing Indicator in One of Health Care Facilities in Bandung. 5(3). https://doi.org/10.15416/ijcp.2016.5.3.225
DiPiro, J. T., Yee, G. C., Posey, L. M., Haines, S. T., Nolin, T. D., & Ellingrod, V. (2020). Pharmacotherapy: A Pathophysiologic Approach. McGraw-Hill Education. accesspharmacy.mhmedical.com/content.aspx?aid=1198986456
Enato, E. F. O., & Chima, I. E. (2011). Evaluation of drug utilization patterns and patient care practices. West African Journal of Pharmacy, 22(1), 36–41. http://fwww.journalmanagers.org/index.php/wajp/article/viewFile/8/6
Eusebi, L. H., Ratnakumaran, R., Yuan, Y., Solaymani-dodaran, M., Bazzoli, F., & Ford, A. C. (2017). Global Prevalence Of, And Risk Factors For, Gastro-Oesophageal Reflux Symptoms: A Meta-Analysis. 1–11. https://doi.org/10.1136/gutjnl-2016-313589
Friyanto, D., Lestari, S., Karawang, P., & Karawang, P. (2002). Analisis Penggunaan Obat Gastroesophageal Reflux Disease ( Gerd ) Pada Pasien Rawat Jalan Di Rumah Sakit Umum Daerah Karawang Disease ( Gerd ) Pada Pasien Rawat Jalan Di Rumah Sakit Umum Daerah. Pharma Xplore?: Jurnal Ilmiah Farmasi, 4(1), 240–247. https://doi.org/DOI: https://doi.org/10.36805/jpx.v4i1.614
Guruge, L., Shanika, T., Reynolds, A., Pattison, S., & Braund, R. (2023). Proton Pump Inhibitor Use?: Systematic Review Of Global Trends And Practices. European Journal of Clinical Pharmacology, 79(9), 1159–1172. https://doi.org/10.1007/s00228-023-03534-z.
Hennessy, S., Bilker, W. B., Zhou L., et al. (2003). Retrospective Drug Utilization Review, Prescribing Errors, and Clinical Outcomes. JAMA, 290(11):1494–1499. https://doi.org/10.1001/jama.290.11.1494
Kazakova, T., Danoff, R., Esteva, I., & Shchurin, A. (2023). Gastro-Esophageal Reflux Disease In Primary Care Practice: A Narrative Review. 1–11. https://doi.org/10.21037/aoe-21-62
Kementerian Kesehatan RI. (2011). Modul Penggunaan Obat Rasional.
Kim, S. Y., Jung, H., Lim, J., Kim, T. O., Choe, A. R., Tae, C. H., Shim, K., & Moon, C. M. (2019). Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease. 34(21), 1–15.
Nishizawa, T., Suzuki, H., Kanai, T., & Yahagi, N. (2015). Proton pump inhibitor alone vs proton pump inhibitor plus mucosal protective agents for endoscopic submucosal dissection induced ulcer?: a systematic review and meta analysis. 56(2), 85–90. https://doi.org/10.3164/jcbn.14
Patala, R., Tandi, J., Ulzmi, N., & Fahruddin, F. (2021). Rasionalitas Penggunanaan Obat Pada.Pasien GERD Di Instalasi Rawat Inap Rumah Sakit Umum Anutapura Palu. JPSCR: Journal of Pharmaceutical Science and Clinical Research, 6(1), 62. https://doi.org/10.20961/jpscr.v6i1.43170
Peery, A. F., Crockett, S. D., Murphy, C. C., Jennifer, L., Dellon, E. S., Williams, J. L., Elizabeth, T., Shaheen, N. J., Barritt, A. S., Sarah, R., Kochar, B., Barnes, E. L., & Fan, Y. C. (2020). Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018. 156(1), 254–272. https://doi.org/10.1053/j.gastro.2018.08.063.Burden
Perkumpulan Gastroenterologi Indonesia. (2022). Konsensus Nasional Penatalaksanaan GERD di Indonesia (Revisi 2022). PIP Interna.
Rahman, A., Maulidina, W., & Kosasih, E. D. (2018). Gambaran Terapi Awal Pada Pasien Gerd ( Gastroesophageal Initial Therapy For Gerd ( Gastroesophageal Reflux Disease ) Patients In Internist Departement Of Rsud Dr . Soekardjo. Jurnal Kesehatan Poltekkes Kemenkes RI Pangkalpinang, 2(6), 69–76.
Santika, N. Y., Desnita, R., & Yuswar, M. A. (2019). Evaluasi Penggunaan Obat Tukak Peptik pada Pasien Tukak Peptik di Instalasi Rawat Inap RSUD Sultan Syarif Mohamad Alkadrie Pontianak. Majalah Farmaseutik, 15(1), 1–15.
Setiawan, M. A., Fasrini, U. U., Amir, A., & Miro, S. (2021). Characteristics of Gastroesophageal Reflux Disease ( GERD ) Patients at RSUP Dr . M . Djamil Padang during 2018-2021 Period?: A Cross-Sectional Study. 24(3).
Shaqran, T. M., Ismaeel, M. M., Alnuaman, A. A., Ahmad, F. A. Al, Albalawi, G. A., Almubarak, J. N., Alharbi, R. S., Alaqidi, R. S., & Alali, Y. A. (2023). Epidemiology , Causes , and Management of Gastro-esophageal Reflux Disease?: A Systematic Review. 15(10). https://doi.org/10.7759/cureus.47420
Simadibrata, M., & Adiwinata, R. (2017). Current Issues of Gastroenterology in Indonesia. 49(3), 270–278.
Suherman, L. P., Ramdani, R., Septiani, V., Indrayani, W., & Nurul, A. (2021). Pola Penggunaan Obat Pada Pasien Gastroesophageal Reflux Disease (Gerd) Di Salah Satu Rumah Sakit Di Bandung. Pharmacoscript, 4(2), 208–219.
Syam, A. F., Syam, A. F., Hapsari, F. C. P., & Makmun, D. (2016). The Prevalence and Risk Factors of GERD among Indonesian Medical Doctors. Makara Journal of Health Research Volume, 20(2), 35–40. https://doi.org/10.7454/msk.v20i2.5740
Vermeijden, J. R., Tytgat, G. N. J., Schotborgh, R. H., Dekker, W., Vd Boomgaard, D. M., Van Olffen, G. H., Schrijver, M., Vosmaer, G. D. C., & Dekkers, C. P. M. (1992). Combination Therapy of Sucralfate and Ranitidine, Compared with Sucralfate Monotherapy, in Patients with Peptic Reflux Esophagitis. Scandinavian Journal of Gastroenterology, 27(2), 81–84. https://doi.org/10.3109/00365529209165421
Vg, M. P., Mcfarland, L. V, Thacker, H. P., Puri, R., & Lawate, P. S. (2024). Efficacy and Safety of Omeprazole for the Treatment of Acid Peptic Disorders?: A Systematic Review and Meta-Analysis. 2024. https://doi.org/10.1155/2024/9990554
Yamasaki, T., Hemond, C., Eisa, M., Ganocy, S., & Fass, R. (2018). The Changing Epidemiology of Gastroesophageal Reflux Disease: Are Patients Getting Younger? Journal Neurogastroenterol Motil, 24(4), 559–569.
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