The potential of honey from Apis cerana in preventing chronic inflammation by downregulating the NF-?B pathway
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Published:
Mar 13, 2024
Keywords:
A.cerana, Docking, NF-ĸB
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Abstract
Chronic inflammation is an inflammatory condition that persists over a long period of time causing tissue damage and contributing to the development of chronic diseases such as arthritis, heart disease, or certain autoimmune conditions. The protein that plays a role in this regulation is the up-regulation of NF-?B, this is the aim of this research, namely to determine the potential of the compounds contained in A.cerana honey to bind with NF-?B. The research stages carried out were preparing the NF-?B protein structure database, protein preparation using the Yasara application, structure preparation and optimization using the Chemaxon application, as well as validating the molecular docking method and docking of compounds from A.cerana honey on the NF-?B protein using the PLANT application. The research results show that Ellagic acid, Taxifolin, Quercetin and Chrysin have affinity and form hydrogen bonds with the NF-?B protein. The binding energy between Ellagic acid, Taxifolin, Quercetin and Chrysin with the NF-?B protein respectively is 78,822; -64.89; -64,872 and -64,935. Ellagic acid, Taxifolin, Quercetin and Chrysin have potential anti-inflammatory activity through binding to the NF-?B protein, thereby preventing the inflammatory process.
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How to Cite
Hadi, S., Setiawan, D., Sukmana, M. L. Q., & Nastiti, K. (2024). The potential of honey from Apis cerana in preventing chronic inflammation by downregulating the NF-?B pathway. Journal of Midwifery and Nursing, 6(2), 424-430. https://doi.org/10.35335/jmn.v6i2.4965
References
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Saputri, K. E., Fakhmi, N., Kusumaningtyas, E., Priyatama, D., & Santoso, B. (2016). Docking Molekular Potensi Anti Diabetes Melitus Tipe 2 Turunan Zerumbon Sebagai Inhibitor Aldosa Reduktase Dengan Autodock-Vina. Chimica et Natura Acta, 4(1), 16. https://doi.org/10.24198/cna.v4.n1.10443
Sutomo, S., & Pratama, M. R. F. (2020). Measuring the potential antioxidant activity of methyl gallate: Molecular docking study. Thai Journal of Pharmaceutical Sciences, 44(1), 14–22.
Wu, J., Han, B., Zhao, S., Zhong, Y., Han, W., Gao, J., & Wang, S. (2022). Bioactive characterization of multifloral honeys from Apis cerana cerana, Apis dorsata, and Lepidotrigona flavibasis. Food Research International (Ottawa, Ont.), 161, 111808. https://doi.org/10.1016/j.foodres.2022.111808
Yong, Y. K., Zakaria, Z. A., Kadir, A. A., Somchit, M. N., Ee Cheng Lian, G., & Ahmad, Z. (2013). Chemical constituents and antihistamine activity of Bixa orellana leaf extract. BMC Complementary and Alternative Medicine, 13(1), 1–7.
Zhou, H.-X., & Pang, X. (2018). Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation. Chemical Reviews, 118(4), 1691–1741. https://doi.org/10.1021/acs.chemrev.7b00305
Arfiandi, A., Nofita, D., & Fadjria, N. (2022). Efek Antiinflamasi Ekstrak Etanol Daun Putri Malu (Mimosa pudica Linn). Journal of Pharmaceutical And Sciences, 5, 274–278. https://doi.org/10.36490/journal-jps.com.v5i2.145
Bitencourt-Ferreira, G., Veit-Acosta, M., & de Azevedo, W. F. J. (2019). Hydrogen Bonds in Protein-Ligand Complexes. Methods in Molecular Biology (Clifton, N.J.), 2053, 93–107. https://doi.org/10.1007/978-1-4939-9752-7_7
C, S., S, D. K., Ragunathan, V., Tiwari, P., A, S., & P, B. D. (2022). Molecular docking, validation, dynamics simulations, and pharmacokinetic prediction of natural compounds against the SARS-CoV-2 main-protease. Journal of Biomolecular Structure & Dynamics, 40(2), 585–611. https://doi.org/10.1080/07391102.2020.1815584
ChemAxon. (2016). ChemAxon - Software Solutions and Services for Chemistry and Biology. In MarvinSketch, Version 16.10.31. https://chemaxon.com/
Chen, W., Gunther, T., Baughman, H., & Komives, E. (2023). Site-specific incorporation of biophysical probes into NF-?B with non-canonical amino acids. Methods (San Diego, Calif.), 213. https://doi.org/10.1016/j.ymeth.2023.03.004
Durkan, K., Acar Ichedef, C., Yurt Kilcar, A., & Karayildirim, C. (2023). In vivo behavior of Technetium-99m labeled ibuprofen in infection and inflamation animal models. Drug Development and Industrial Pharmacy, 49, 1–8. https://doi.org/10.1080/03639045.2023.2235009
Ermi?, I. S., Deveci, E., & A??r, F. (2023). NF-?B expression in endometriosis induced rat uterine tissue. Journal of Drug Delivery and Therapeutics, 13, 33–36. https://doi.org/10.22270/jddt.v13i4.6011
Gantait, S., Subrahmanyeswari, T., Kamble, S., & Singh, S. (2024). Strategies for the ameliorated production of pharmaceutically important glycosides via plant cell culture (pp. 51–74). https://doi.org/10.1016/B978-0-443-18925-8.00001-5
Garas, M. (2017). Signs Of Inflamation In The Airways In Children With Exercise-Induced Bronchial Asthma. Inter Collegas, 4, 14–19. https://doi.org/10.35339/ic.4.1.14-19
Hadi, S., Viogenta, P., Setiawan, D., Nastiti, K., & Rahmadani. (2023). Exploring Potential ADH Inhibitors Among Compounds from the Genus Combretum Using a Pharmacophore Method. Azerbaijan Medical Journal, 63(9), 10329–10339. https://doi.org/www.azerbaijanmedicaljournal.net/article/exploring-potential-adh-inhibitors-among-compounds-from-the-genus-combretum-using-a-pharmacophore-method
Krieger, E., & Vriend, G. (2014). YASARA View—molecular graphics for all devices—from smartphones to workstations. Bioinformatics, 30(20), 2981–2982. https://doi.org/10.1093/bioinformatics/btu426
Liu, P., Li, Y., Wang, W., Bai, Y., Jia, H., Yuan, Z., & Yang, Z. (2022). Role and mechanisms of the NF-?B signaling pathway in various developmental processes. Biomedicine & Pharmacotherapy, 153, 113513. https://doi.org/10.1016/j.biopha.2022.113513
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017). NF-?B signaling in inflammation. Signal Transduction and Targeted Therapy, 2(1), 17023. https://doi.org/10.1038/sigtrans.2017.23
Mukherjee, A. G., & Gopalakrishnan, A. (2023). The interplay of arsenic, silymarin, and NF-?B pathway in male reproductive toxicity: A review. Ecotoxicology and Environmental Safety, 252, 114614. https://doi.org/10.1016/j.ecoenv.2023.114614
Naqvi, S. A. R., Mahmood, N., Naz, S., Hussain, Z., Sherazi, T. A., Khan, Z. A., Shahzad, S. A., Yar, M., Bukhari, I. H., & Ahmad, M. (2013). Antioxidant and antibacterial evaluation of honey bee hive extracts using in vitro models. Mediterranean Journal of Nutrition and Metabolism, 6(3), 247–253.
Salsabila, S., & Sudiono, J. (2022). Efek Antiinflamasi Ekstrak Kulit Tamarillo: Pemeriksaan Kadar IL-6 Tikus Pasca Induksi Karagenin. Jurnal Biomedika Dan Kesehatan, 5, 75–81. https://doi.org/10.18051/JBiomedKes.2022.v5.75-81
Saputra, D. (2018). Molecular Docking Sianidin dan Peonidin sebagai Antiinflamasi pada Aterosklerosis Secara In Silico. Jurnal Farmasi Udayana, 28. https://doi.org/10.24843/JFU.2018.v07.i01.p04
Saputri, K. E., Fakhmi, N., Kusumaningtyas, E., Priyatama, D., & Santoso, B. (2016). Docking Molekular Potensi Anti Diabetes Melitus Tipe 2 Turunan Zerumbon Sebagai Inhibitor Aldosa Reduktase Dengan Autodock-Vina. Chimica et Natura Acta, 4(1), 16. https://doi.org/10.24198/cna.v4.n1.10443
Sutomo, S., & Pratama, M. R. F. (2020). Measuring the potential antioxidant activity of methyl gallate: Molecular docking study. Thai Journal of Pharmaceutical Sciences, 44(1), 14–22.
Wu, J., Han, B., Zhao, S., Zhong, Y., Han, W., Gao, J., & Wang, S. (2022). Bioactive characterization of multifloral honeys from Apis cerana cerana, Apis dorsata, and Lepidotrigona flavibasis. Food Research International (Ottawa, Ont.), 161, 111808. https://doi.org/10.1016/j.foodres.2022.111808
Yong, Y. K., Zakaria, Z. A., Kadir, A. A., Somchit, M. N., Ee Cheng Lian, G., & Ahmad, Z. (2013). Chemical constituents and antihistamine activity of Bixa orellana leaf extract. BMC Complementary and Alternative Medicine, 13(1), 1–7.
Zhou, H.-X., & Pang, X. (2018). Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation. Chemical Reviews, 118(4), 1691–1741. https://doi.org/10.1021/acs.chemrev.7b00305
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