Effectiveness of massage therapy to reduce bilirubin levels in neonates with hyperbilirubinemia a systematic review and metaanalysis
Article Sidebar
Published:
Jan 30, 2024
Keywords:
Bilirubin, Hyperbilirubin, Massager, Neonates
Section
Articles
Statistics Article
Article View : 305 Times
Main Article Content
Abstract
Hyperbilirubinemia in neonates is often a health problem that can cause serious complications such as encephalopathy, kernicterus, and even death if not treated properly. Currently, treatments focus on phototherapy, which despite its positive impact, also has the potential to cause negative effects such as diarrhea, dehydration, skin rash, blue baby syndrome, and skin darkening. Massage therapy is emerging as a potential intervention to reduce the need for phototherapy and lower bilirubin levels. Although massage therapy shows a positive impact, it has not been proven to be fully effective in lowering bilirubin levels in neonates with hyperbilirubinemia. The aim of this systematic review is to assess the effectiveness of massage therapy on reducing bilirubin levels in neonates with hyperbilirubinemia. In this review, 127 articles were selected, and the results showed that massage therapy was effective in reducing bilirubin levels in neonates. In conclusion, massage therapy can be implemented in health services as an effective approach to treat hyperbilirubinemia in neonates.
Article Details
How to Cite
Natashia, D. ., Rahmania, S. ., Yulianti, D. A. ., Laily, D. ., Istinganah, I., & Humairah, F. . (2024). Effectiveness of massage therapy to reduce bilirubin levels in neonates with hyperbilirubinemia a systematic review and metaanalysis. Journal of Midwifery and Nursing, 6(1), 345-355. https://doi.org/10.35335/jmn.v6i1.4800
References
Ahmadipour, S., Mardani, M., Mohsenzadeh, A., Baharvand, P., & Nazeri, M. (2019). The Lowering of Bilirubin Levels in Full-Term Newborns by the Effect of Combined Massage Therapy and Phototherapy Practice. American Journal of Perinatology. https://doi.org/10.1055/s-0039-1685493
Basiri?Moghadam, Basiri?Moghadam, Kianmehr, &, & Jani. (2015). The effect of massage on neonatal jaundice in stable preterm newborn infants: A randomized controlled trial. The Journal of the Pakistan Medical Association.
Bienia, A., Wieche?-Cudak, O., Murzyn, A. A., & Krzykawska-Serda, M. (2021). Photodynamic therapy and hyperthermia in combination treatment—Neglected forces in the fight against cancer. Pharmaceutics, 13(8), 1147.
Chen, J., Sadakata, M., Ishida, M., Sekizuka, N., & Sayama, M. (2011). Baby massage ameliorates neonatal jaundice in full-term newborn infants. Tohoku Journal of Experimental Medicine, 223(2), 97–102. https://doi.org/10.1620/tjem.223.97
Creeden, J. F., Gordon, D. M., Stec, D. E., & Hinds Jr, T. D. (2021). Bilirubin as a metabolic hormone: The physiological relevance of low levels. American Journal of Physiology-Endocrinology and Metabolism, 320(2), E191–E207.
Diego, M. A., Field, T., & Hernandez-Reif, M. (2005). Vagal activity, gastric motility, and weight gain in massaged preterm neonates. Journal of Pediatrics, 147(1), 50–55. https://doi.org/10.1016/j.jpeds.2005.02.023
Du, L., Ma, X., Shen, X., Bao, Y., Chen, L., & Bhutani, V. K. (2021). Neonatal hyperbilirubinemia management: Clinical assessment of bilirubin production. Seminars In Perinatology, 45(1), 151351.
Fathi, F., & Ahmed, M. (2017). Effect of Infant Massage Oil on Jundiced Neonate Undergoing Phototherapy. Egyptian Journal of Health Care, 8(4), 347–357. https://doi.org/10.21608/ejhc.2017.54575
Firmino, C., Rodrigues, M., Franco, S., Ferreira, J., Simões, A. R., Castro, C., & Fernandes, J. B. (2022). Nursing Interventions That Promote Sleep in Preterm Newborns in the Neonatal Intensive Care Units: An Integrative Review. International Journal of Environmental Research and Public Health, 19(17), 10953.
Fonna, M. R., Kania, N., & Nasution, G. T. D. (2021). Characteristics of Neonates with Hyperbilirubinemia in Cileunyi, West Java. Althea Medical Journal, 8(3), 155–158.
Gözen, D., Y?lmaz, Ö. E., Dur, ?., Ça?layan, S., & Ta?tekin, A. (2019). Transcutaneous bilirubin levels of newborn infants performed abdominal massage: A randomized controlled trial. Journal for Specialists in Pediatric Nursing, 24(2), 1–8. https://doi.org/10.1111/jspn.12237
Hansen, T. W. R. (2021). Narrative Review of the Epidemiology of Neonatal Jaundice. Pediatric Medicine, 4(18), 1–14. https://doi.org/10.21037/pm-21-4
Hansen, T. W. R., Maisels, M. J., Ebbesen, F., Vreman, H. J., Stevenson, D. K., Wong, R. J., & Bhutani, V. K. (2020). Sixty years of phototherapy for neonatal jaundice–from serendipitous observation to standardized treatment and rescue for millions. Journal of Perinatology, 40(2), 180–193.
Jazayeri, Z., Sajadi, M., Dalvand, H., & Zolfaghari, M. (2021). Comparison of the effect of foot reflexology and body massage on physiological indicators and bilirubin levels in neonates under phototherapy. Complementary Therapies in Medicine, 59, 102684. https://doi.org/10.1016/j.ctim.2021.102684
Kemenkes RI. (2020). Injeksi 2018. In Health Statistics.
Keputusan Mentri Kesehatan Republik Indonesia. (2019). Pedoman Nasional Pelayanan Kedokteran Tata Laksana Hiperbilrubinemia. Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 224(11), 122–130.
Kianmehr, M., Moslem, A., Moghadam, K. B., Naghavi, M., Noghabi, S. P., & Moghadam, M. B. (2022). The Effect of Field Massage on Bilirubin Levels in Neonates with Hyperbilirubinemia. KnE Life Sciences, March 2015. https://doi.org/10.18502/kls.v7i2.10327
Korkmaz, G., & Esenay, F. I. (2020). Effects of Massage Therapy on Indirect Hyperbilirubinemia in Newborns Who Receive Phototherapy. JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing, 49(1), 91–100. https://doi.org/10.1016/j.jogn.2019.11.004
Lin, C. H., Yang, H. C., Cheng, C. S., & Yen, C. E. (2018). Effects of infant massage on jaundiced neonates undergoing phototherapy. Italian Journal of Pediatrics, 41(1), 1–6. https://doi.org/10.1186/s13052-015-0202-y
Mrljak, R., Arnsteg Danielsson, A., Hedov, G., & Garmy, P. (2022). Effects of infant massage: a systematic review. International Journal of Environmental Research and Public Health, 19(11), 6378.
Muniyappa, P., & Kelley, D. (2020). Hyperbilirubinemia in pediatrics: Evaluation and care. Current Problems in Pediatric and Adolescent Health Care, 50(8), 100842.
Namnabati, M., Mohammadizadeh, M., & Sardari, S. (2018). The effect of home-based phototherapy on parental stress in mothers of infants with neonatal jaundice. Journal of Neonatal Nursing, 1(1), 1–4. https://doi.org/10.1016/j.jnn.2018.09.001
O’Dea, R. E., Lagisz, M., Jennions, M. D., Koricheva, J., Noble, D. W. A., Parker, T. H., Gurevitch, J., Page, M. J., Stewart, G., & Moher, D. (2021). Preferred reporting items for systematic reviews and meta?analyses in ecology and evolutionary biology: a PRISMA extension. Biological Reviews, 96(5), 1695–1722.
Sari, H. E., & Yulianti, N. T. (2022). Effectivenss of Massage Therapy for the Treatment of Neonatal Jaundice: a Systematic Review and Meta-Analysis. The 9th International Conference on Public Health, 23(24), 430–438.
Sarkis-Onofre, R., Catalá-López, F., Aromataris, E., & Lockwood, C. (2021). How to properly use the PRISMA Statement. Systematic Reviews, 10(1), 1–3.
Sead, G. K., Montaser, B. A., Omar, T. A., Omar, Z. A., & Alkorashy, A. A. (2020). p53 as an apoptotic marker before and after phototherapy in hyperbilirubinemic neonates. Menoufia Medical Journal, 33(3), 930.
Senbekov, M., Saliev, T., Bukeyeva, Z., Almabayeva, A., Zhanaliyeva, M., Aitenova, N., Toishibekov, Y., & Fakhradiyev, I. (2020). The recent progress and applications of digital technologies in healthcare: a review. International Journal of Telemedicine and Applications, 2020.
Shirzadfar, H., & Sheikhi, K. (2020). An Introduction on Different Types of Phototherapy Devices to Cure Neonatal Jaundice: Internal Structure of Light Sources & Protection System. Journal of Clinical and Translational Neonatology, 1(1), 1–10.
Shoris, I., Gover, A., Toropine, A., Iofe, A., Zoabi-Safadi, R., Tsuprun, S., & Riskin, A. (2023). “Light” on Phototherapy—Complications and Strategies for Shortening Its Duration, A Review of the Literature. Mdpi, 10(1), 1–21.
Suely, N., Oliveira, F. De, Guimarães, R. P., Cavalcante, V., Adilson, A., & Lima, S. De. (2015). Green Teeth Resulting from Neonatal Hyperbilitubinemia: Report of a Case. Otolaryngologia Polska, 90(2), 155–160. https://doi.org/10.1016/j.pepo.2014.12.004
Travers, J. L., Hirschman, K. B., & Naylor, M. D. (2020). Adapting Andersen’s expanded behavioral model of health services use to include older adults receiving long-term services and supports. BMC Geriatrics, 20(1), 1–16.
Wang, J., Guo, G., Li, A., Cai, W. E. N. Q. I., & Wang, X. (2021). Challenges of phototherapy for neonatal hyperbilirubinemia (Review). Experimental and Therapeutic Medicine, 21(1), 1–11. https://doi.org/10.3892/etm.2021.9662
Watson, R. L. (2009). Hyperbilirubinemia. Pediatrics, 21(1), 97–120. https://doi.org/10.1016/j.ccell.2008.11.001
Zhang, M., Tang, J., He, Y., Li, W., Chen, Z., Xiong, T., Qu, Y., Li, Y., & Mu, D. (2021). Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia. BMJ Open, 11(1), 1–11. https://doi.org/10.1136/bmjopen-2020-040182
Zsanett Csoma, Peter Hencz, Hajnalka Orvos, Lajos Kemeny, Attila Dobozy, Eva Dosa-Racz, Zsuzsanna Erdei, D. B. and J. O. (2007). Neonatal Blue-Light Phototherapy Could Increase the Risk of Dysplastic Nevus Development. Pediatrics, 119(5), 1035–1036. https://doi.org/10.1542/peds.2007-0468
Basiri?Moghadam, Basiri?Moghadam, Kianmehr, &, & Jani. (2015). The effect of massage on neonatal jaundice in stable preterm newborn infants: A randomized controlled trial. The Journal of the Pakistan Medical Association.
Bienia, A., Wieche?-Cudak, O., Murzyn, A. A., & Krzykawska-Serda, M. (2021). Photodynamic therapy and hyperthermia in combination treatment—Neglected forces in the fight against cancer. Pharmaceutics, 13(8), 1147.
Chen, J., Sadakata, M., Ishida, M., Sekizuka, N., & Sayama, M. (2011). Baby massage ameliorates neonatal jaundice in full-term newborn infants. Tohoku Journal of Experimental Medicine, 223(2), 97–102. https://doi.org/10.1620/tjem.223.97
Creeden, J. F., Gordon, D. M., Stec, D. E., & Hinds Jr, T. D. (2021). Bilirubin as a metabolic hormone: The physiological relevance of low levels. American Journal of Physiology-Endocrinology and Metabolism, 320(2), E191–E207.
Diego, M. A., Field, T., & Hernandez-Reif, M. (2005). Vagal activity, gastric motility, and weight gain in massaged preterm neonates. Journal of Pediatrics, 147(1), 50–55. https://doi.org/10.1016/j.jpeds.2005.02.023
Du, L., Ma, X., Shen, X., Bao, Y., Chen, L., & Bhutani, V. K. (2021). Neonatal hyperbilirubinemia management: Clinical assessment of bilirubin production. Seminars In Perinatology, 45(1), 151351.
Fathi, F., & Ahmed, M. (2017). Effect of Infant Massage Oil on Jundiced Neonate Undergoing Phototherapy. Egyptian Journal of Health Care, 8(4), 347–357. https://doi.org/10.21608/ejhc.2017.54575
Firmino, C., Rodrigues, M., Franco, S., Ferreira, J., Simões, A. R., Castro, C., & Fernandes, J. B. (2022). Nursing Interventions That Promote Sleep in Preterm Newborns in the Neonatal Intensive Care Units: An Integrative Review. International Journal of Environmental Research and Public Health, 19(17), 10953.
Fonna, M. R., Kania, N., & Nasution, G. T. D. (2021). Characteristics of Neonates with Hyperbilirubinemia in Cileunyi, West Java. Althea Medical Journal, 8(3), 155–158.
Gözen, D., Y?lmaz, Ö. E., Dur, ?., Ça?layan, S., & Ta?tekin, A. (2019). Transcutaneous bilirubin levels of newborn infants performed abdominal massage: A randomized controlled trial. Journal for Specialists in Pediatric Nursing, 24(2), 1–8. https://doi.org/10.1111/jspn.12237
Hansen, T. W. R. (2021). Narrative Review of the Epidemiology of Neonatal Jaundice. Pediatric Medicine, 4(18), 1–14. https://doi.org/10.21037/pm-21-4
Hansen, T. W. R., Maisels, M. J., Ebbesen, F., Vreman, H. J., Stevenson, D. K., Wong, R. J., & Bhutani, V. K. (2020). Sixty years of phototherapy for neonatal jaundice–from serendipitous observation to standardized treatment and rescue for millions. Journal of Perinatology, 40(2), 180–193.
Jazayeri, Z., Sajadi, M., Dalvand, H., & Zolfaghari, M. (2021). Comparison of the effect of foot reflexology and body massage on physiological indicators and bilirubin levels in neonates under phototherapy. Complementary Therapies in Medicine, 59, 102684. https://doi.org/10.1016/j.ctim.2021.102684
Kemenkes RI. (2020). Injeksi 2018. In Health Statistics.
Keputusan Mentri Kesehatan Republik Indonesia. (2019). Pedoman Nasional Pelayanan Kedokteran Tata Laksana Hiperbilrubinemia. Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 224(11), 122–130.
Kianmehr, M., Moslem, A., Moghadam, K. B., Naghavi, M., Noghabi, S. P., & Moghadam, M. B. (2022). The Effect of Field Massage on Bilirubin Levels in Neonates with Hyperbilirubinemia. KnE Life Sciences, March 2015. https://doi.org/10.18502/kls.v7i2.10327
Korkmaz, G., & Esenay, F. I. (2020). Effects of Massage Therapy on Indirect Hyperbilirubinemia in Newborns Who Receive Phototherapy. JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing, 49(1), 91–100. https://doi.org/10.1016/j.jogn.2019.11.004
Lin, C. H., Yang, H. C., Cheng, C. S., & Yen, C. E. (2018). Effects of infant massage on jaundiced neonates undergoing phototherapy. Italian Journal of Pediatrics, 41(1), 1–6. https://doi.org/10.1186/s13052-015-0202-y
Mrljak, R., Arnsteg Danielsson, A., Hedov, G., & Garmy, P. (2022). Effects of infant massage: a systematic review. International Journal of Environmental Research and Public Health, 19(11), 6378.
Muniyappa, P., & Kelley, D. (2020). Hyperbilirubinemia in pediatrics: Evaluation and care. Current Problems in Pediatric and Adolescent Health Care, 50(8), 100842.
Namnabati, M., Mohammadizadeh, M., & Sardari, S. (2018). The effect of home-based phototherapy on parental stress in mothers of infants with neonatal jaundice. Journal of Neonatal Nursing, 1(1), 1–4. https://doi.org/10.1016/j.jnn.2018.09.001
O’Dea, R. E., Lagisz, M., Jennions, M. D., Koricheva, J., Noble, D. W. A., Parker, T. H., Gurevitch, J., Page, M. J., Stewart, G., & Moher, D. (2021). Preferred reporting items for systematic reviews and meta?analyses in ecology and evolutionary biology: a PRISMA extension. Biological Reviews, 96(5), 1695–1722.
Sari, H. E., & Yulianti, N. T. (2022). Effectivenss of Massage Therapy for the Treatment of Neonatal Jaundice: a Systematic Review and Meta-Analysis. The 9th International Conference on Public Health, 23(24), 430–438.
Sarkis-Onofre, R., Catalá-López, F., Aromataris, E., & Lockwood, C. (2021). How to properly use the PRISMA Statement. Systematic Reviews, 10(1), 1–3.
Sead, G. K., Montaser, B. A., Omar, T. A., Omar, Z. A., & Alkorashy, A. A. (2020). p53 as an apoptotic marker before and after phototherapy in hyperbilirubinemic neonates. Menoufia Medical Journal, 33(3), 930.
Senbekov, M., Saliev, T., Bukeyeva, Z., Almabayeva, A., Zhanaliyeva, M., Aitenova, N., Toishibekov, Y., & Fakhradiyev, I. (2020). The recent progress and applications of digital technologies in healthcare: a review. International Journal of Telemedicine and Applications, 2020.
Shirzadfar, H., & Sheikhi, K. (2020). An Introduction on Different Types of Phototherapy Devices to Cure Neonatal Jaundice: Internal Structure of Light Sources & Protection System. Journal of Clinical and Translational Neonatology, 1(1), 1–10.
Shoris, I., Gover, A., Toropine, A., Iofe, A., Zoabi-Safadi, R., Tsuprun, S., & Riskin, A. (2023). “Light” on Phototherapy—Complications and Strategies for Shortening Its Duration, A Review of the Literature. Mdpi, 10(1), 1–21.
Suely, N., Oliveira, F. De, Guimarães, R. P., Cavalcante, V., Adilson, A., & Lima, S. De. (2015). Green Teeth Resulting from Neonatal Hyperbilitubinemia: Report of a Case. Otolaryngologia Polska, 90(2), 155–160. https://doi.org/10.1016/j.pepo.2014.12.004
Travers, J. L., Hirschman, K. B., & Naylor, M. D. (2020). Adapting Andersen’s expanded behavioral model of health services use to include older adults receiving long-term services and supports. BMC Geriatrics, 20(1), 1–16.
Wang, J., Guo, G., Li, A., Cai, W. E. N. Q. I., & Wang, X. (2021). Challenges of phototherapy for neonatal hyperbilirubinemia (Review). Experimental and Therapeutic Medicine, 21(1), 1–11. https://doi.org/10.3892/etm.2021.9662
Watson, R. L. (2009). Hyperbilirubinemia. Pediatrics, 21(1), 97–120. https://doi.org/10.1016/j.ccell.2008.11.001
Zhang, M., Tang, J., He, Y., Li, W., Chen, Z., Xiong, T., Qu, Y., Li, Y., & Mu, D. (2021). Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia. BMJ Open, 11(1), 1–11. https://doi.org/10.1136/bmjopen-2020-040182
Zsanett Csoma, Peter Hencz, Hajnalka Orvos, Lajos Kemeny, Attila Dobozy, Eva Dosa-Racz, Zsuzsanna Erdei, D. B. and J. O. (2007). Neonatal Blue-Light Phototherapy Could Increase the Risk of Dysplastic Nevus Development. Pediatrics, 119(5), 1035–1036. https://doi.org/10.1542/peds.2007-0468
Copyright and Licensing
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.